Brain development during adolescence: A mixed-longitudinal investigation of cortical thickness, surface area, and volume

N Vijayakumar; NB Allen; G Youssef; M Dennison; M Yücel; JG Simmons; S Whittle

Journal article

Brain development during adolescence: A mixed-longitudinal investigation of cortical thickness, surface area, and volume

N Vijayakumar, NB Allen, G Youssef, M Dennison, M Yücel, JG Simmons, S Whittle

Human Brain Mapping | WILEY-BLACKWELL | Published : 2016

DOI: 10.1002/hbm.23154

Abstract

What we know about cortical development during adolescence largely stems from analyses of cross-sectional or cohort-sequential samples, with few studies investigating brain development using a longitudinal design. Further, cortical volume is a product of two evolutionarily and genetically distinct features of the cortex - thickness and surface area, and few studies have investigated development of these three characteristics within the same sample. The current study examined maturation of cortical thickness, surface area and volume during adolescence, as well as sex differences in development, using a mixed longitudinal design. 192 MRI scans were obtained from 90 healthy (i.e., free from lif..

View full abstract

University of Melbourne Researchers

Nandita Vijayakumar Author

Nick Allen Author

Julian Simmons Author

Sarah Whittle Author

Related Projects (3)

Brain development during adolescence and the emergence of depression: A longitudinal MRI study.

Traditionally mental health services have focused on established disorders. Whilst significant gains in outcomes have been obtained in other..

EMERGING SEVERE MENTAL ILLNESS IN YOUNG PEOPLE

Mental disorders, such as psychotic and severe mood disorders, are the largest cause of disability in Australia. However, there is still lit..

Sensitivity to the environment: Risk and resilience for adolescent depression

Depression is among the leading causes of disability and disease burden throughout the world. Little is known about how biological and envir..

Grants

Awarded by National Health and Medical Research Council (NHMRC; Australia)

Awarded by Australian Research Council (ARC)

Funding Acknowledgements

Contract grant sponsor: Colonial Foundation; National Health and Medical Research Council (NHMRC; Australia; Contract grant number: Program Grant 350241), Australian Research Council (ARC Discovery Grant DP0878136)